Bleomycin Induced Diffuse Alveolar Damage
Brief Discussion
Bleomycin is used in the treatment of squamous cell
carcinoma, lymphoma and testicular neoplasms.
It is concentrated in the
lung, which is therefore a primary target for adverse effects.
Toxicity is
related to the cumulative dose and significantly increased when doses exceed
a total of 400mg.
The frequency and severity of pulmonary toxicity increase
with age, prior or concomitant radiation therapy, oxygen therapy, decreased
renal function, or concomitant treatment with other chemotherapeutic agents.
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