Radiologic Findings

Diffuse GGO with ill-defined nodules
Hepatosplenomegaly
Minimal pleural and pericardial effusion

Pathologic Findings



Brief Discussion

– Malignant endotheliomatosis, Angiotropic large cell lymphoma
– Malignant lymphoma characterized by proliferation of neoplastic lymphoid cells within the vascular lumen
– Predominantly affects vessels in CNS
– Lung involvement at autopsy: ~60%

• 
  CXR
  – Diffuse interstitial infiltrates
  –Normal, minimal bilateral pleural effusion
  
  
• HRCT
  – Patchy areas of GGO of peripheral predominance with mild septal thickening
  – RPC;  expanded alveolar septa and perivascular spaces due to distended septal capillaries, venules, and    arterioles, filled with neoplastic cells, alveolar congestion and hemorrhage
  
  
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