Pathologic Findings



Brief Discussion 

BOOP as  primary cause of respiratory illness
Organization of prior infection (viral, bacterial)
Toxic inhalants (silo-filler’s lung)
Drug toxicity (gold, amiodarone, sulfasalazine,…)
Collagen vascular diseases (RA, lupus, polymyositis,…)
Bronchial obstruction (foreign material, tumors)
Unknown etiology (Idiopathic BOOP or COP)

Amiodarone pulmonary toxicity
5-10% of pts
Within  months of starting therapy
No correlation between the development of drug toxicity and the duration of therapy or total accumulative dose
Daily maintenance dose >400 mg, elderly pts: increased risk
Good Px

Histologic finding
NSIP: TMC manifestation
BOOP: less common and typically occurs in association with NSIP

Radiologic finding
Peripheral located, high attenuated pulmonayr opacities
Characteristics of amiodarone toxicity: high-attenuation abnormalities within the lung, liver, and spleen


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