Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Benign metastasizing leiomyoma
- Radiologic Findings
- Serial chest radiographs and CT scans over a period of 3 years show two slowly growing nodules, located in the RUL and LUL lingular division. The nodules are oval shaped with well-defined margins, and demonstrate no definite FDG uptake at PET/CT scans.
The patient had history of hysterectomy 9 years ago for uterine myoma. VATS lingular segmentectomy of the nodule was performed. Pathologic results were consistent with benign metastasizing leiomyoma (H-caldesmon, desmin, ER, PR: positive, HMB-45, CD34, S100: negative).
- Brief Review
- Benign metastasizing leiomyoma is a rare entity. Lungs are the most common site of metastasis. Women who have undergone hysterectomy for leiomyomas are most commonly affected.. Patients are usually asymptomatic with incidental observation of pulmonary lesions. Nodules can be seen 3 months to 20 years after hysterectomy. Although there have been reports of patient morbidity and mortality from benign metastasizing leiomyoma, the clinical course is usually indolent. Typical radiographic findings include well-circumscribed solitary or multiple pulmonary nodules ranging in size from a few millimeters to several centimeters in diameter scattered among normal lung. A miliary pattern is less common, but has been reported. Typically, nodules are not calcified and do not enhance after IV contrast and demonstrate no significant metabolic activity at PET/CT scans.
- Please refer to
Case 215, Case 394, Case 413, Case 667, Case 847, Case 952, -
- References
- 1. di Scioscio V. et al. J Thorac Imaging. 2009;24:41-4 Benign metastasizing leiomyoma of the lung: PET findings.
2. Abramson S. et al. Benign Metastasizing Leiomyoma Clinical, Imaging, and Pathologic Correlation. Am J Roentgenol. 2001;176:1409-13
- Keywords
- Lung, Benign tumor,