대한흉부영상의학회 Weekly Chest Cases

Courtesy of Eun Jin Chae, M.D., Joon Beom Seo, M.D., Jae-Woo Song, M.D. / Asan Medical Center, Ulsan University, Seoul, Korea
Age/Sex 65 / M
Chief ComplaintDyspnea and febrile sense for 10 days

Diagnosis: Amiodarone-induced pulmonary toxicity
Radiologic Findings: Previous chest radiograph shows patchy consolidation with reticular opacity in left lower lung field. Follow-up chest radiograph shows diffuse ground-glass opacity and consolidation with reticulation in both lungs. The patient has been treated with amiodarone because of atrial fibrillation. HRCT scans show multifocal areas of consolidation, ground-glass attenuation, and irregular linear opacities in both lungs. Mild traction bronchiectasis is noted within the consolidation. Open lung biopsy obtained from left upper lobe showed diffuse temporally uniform interstitial fibroblastic proliferation with multifocal hyaline membrane-like material in alveolar spaces, tightly clustered aggregates of intraalveolar macrophages and a few intraalveolar fibroblastic foci.
The histologic findings were consistent with amiodarone-induced acute interstitial pneumonia and BOOP feature.
Brief Review: Please refer to case 114 and 176
References: Please refer to case 114 and 176
Keywords: Lung, Iatrogenic lung disease, Drug complication,

대한흉부영상의학회 Korean Society of Thoracic Radiology