Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Scrub Typhus (Tsutsugamushi disease)
- Radiologic Findings
- Initial chest PA shows increased interstitial opacities in both lungs. Blunting of bilateral costophrenic angles is noted.
Lung setting of the chest CT images show interlobular septal thickening and multifocal patch ground-glass opacities which are patterns of the interstitial pneumonia in both lungs. Mediastinal setting of chest CT image shows enlargement of both axillary and para-aortic lymph nodes. There are also small amount of bilateral pleural effusion.
Laboratory data of the patient showed positive for O. tsutsugamushi antibody, mild LFT abnormality and increased CRP (C-reactive protein).
- Brief Review
- Scrub typhus (tsutsugamushi disease) is an acute febrile illness caused by Orientia tsutsugamushi, characterized by focal or disseminated vasculitis and perivasculitis, which may involve the lungs, heart, liver, spleen, and central nervous system. Scrub typhus has epidemics in the late fall that affect a wide area of South-East Asia and the Pacific rim including the Korean Peninsula. It is transmitted to humans by the bite of mites or chiggers.
The diagnosis of scrub typhus is based on history of exposure, clinical features and serological testing. The main clinical manifestations are high fever, skin rash, myalgia, lymph node enlargement and characteristic eschar formation at the site of chigger feeding. The clinical course is usually mild and self-limited with spontaneous recovery after a few days, but some patients have a more severe course which may be fatal.
The radiological findings of scrub typhus are variable, ranging from normal to fulminant pulmonary edema. On chest radiography, bilateral diffuse areas of reticulonodular opacity, hilar lymph node enlargement, and septal lines are the most common findings. Airspace consolidation is relatively uncommon and generally appears in the lower zone of both lungs. Unilateral or bilateral pleural effusion is common, found in 12-43% of patients. On high-resolution CT, interlobular septal thickening, axial interstitial thickening, ground-glass opacity, and centriloular nodules with lower lung predilection are common findings. Consolidation and large nodules are less common. CT findings of scrub typhus may reflect cellular infiltration, edema, and hemorrhage caused by vasculitis or may be due to interstitial edema secondary to cardiac involvement.
The differential diagnosis of scrub typhus is pulmonary interstitial edema and pulmonary interstitial pneumonia such as viral pneumonia, Mycoplasma pneumonia, and Pneumocystis Jiroveci pneumonia etc.
- References
- 1. Choi YH, Kim SJ, Lee JY, Pai HJ, Lee KY, Lee YS. Scrub typhus: radiological and clinical findings. Clin Radiol 2000; 55:140-144.
2. Jeong YJ, Kim S, Wook YD, Lee JW, Kim KI, Lee SH. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 2007; 27:161-172.
- Keywords
- Lung, Multiple organ, Infection,