Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Crizotinib associated complex renal cysts
- Radiologic Findings
- Figs 1. Initial chest CT shows irregular nodule in LLL, which biopsy proved lung cancer.
Fig 2-3. The patient have chemotherapy for advanced disease (lymph node metastasis in right supraclavicular area, not shown). After chemotherapy, CT scans shows decreased size of primary lung cancer in LLL. On mediastinal window setting, there are no abnormal findings in abdomen including both kidneys.
Figs 4-5. After 3 months later, CT scan with mediastinal window setting shows newly developed complicated cystic lesion in left kidney and fluid density in right perirenal space. There are no evidence of progression in primary tumor in LLL.
Fig 6. The primary lung cancer was positive ALK translocation. He had treatment with crizotinib for lung cancer.
Fig 7. After 1 year, CT scan show resolution of complicated renal cyst despite continuing crizotinib treatment.
- Brief Review
- Crizotinib is an inhibitor of several receptor tyrosine kinases, including anaplastic lymphoma kinase (ALK), hepatocyte growth factor receptor (HGFR, c-Met), and c-ros oncogene 1. It has been approved for the treatment of advanced ALK-positive non
- References
- 1. Yen-Ting Lin, MD, Yu-Fen Wang, MD, James Chih-Hsin Yang, MD. Development of Renal Cysts after Crizotinib Treatment in Advanced ALK-Positive Non
- Keywords
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Lung, kidney, Drug related disease,