Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Amyloidosis (Nodular Form)
- Radiologic Findings
- Multiple discrete nodules were scattered in the right lung. A nodule in RUL was densely calcified and two small nodules in RLL contained punctate foci of calcifications. VATS biopsy was done for uncalcified nodule in RML to exclude the possibility of lung cancer. Nodular Amyloidosis was confirmed by disclosing amorphous pinkish deposits with Congo-red staining.
- Brief Review
- The term Amyloidosis refers to a group of conditions characterized by extracellular deposition of abnormal protein. It can be classified in primary systemic amyloidosis (64%), localized amyloidosis (31%), and secondary systemic amyloidosis (5%). The main manifestations of localized amyloidosis consisted of single or multiple discrete nodules or masses (nodular amyloidosis), 20% of which had foci of calcification, and thickening of the larynx, trachea, or bronchus (tracheobronchial amyloidosis).
- References
- 1. Utz JP, Swensen SJ, Gertz MA. Pulmonary amyloidosis: the Mayo Clinic experience from 1980 to 1993. Ann Intern Med 1996; 124:407-413.
2. Pickford HA, Swensen SJ, Utz JP. Thoracic cross-sectional imaging of amyloidosis. AJR 1997; 168:351-355.
3. Kim HY, Im JG, Song KS, et al. Localized amyloidosis of the respiratory system: CT features. J Comput Assist Tomogr 1999; 23: 627-631
- Keywords
- Lung, Metabolic and storage lung disesae,