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Weekly Chest CasesArchive of Old Cases

Case No : 1404 Date 2024-09-17

  • Courtesy of Suji Lee / Severance Hospital
  • Age/Sex 48 / F
  • Chief ComplaintConsolidation in chest CT. / R.O.S / P.E: None / Past history: None
  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4

Diagnosis With Brief Discussion

Diagnosis
Pulmonary sequestration
Radiologic Findings
Fig 1. Unremarkable finding in the chest radiography.
Fig 2. Serial low-dose non-contrast chest CT scans shows increasing irregular shape consolidation in left lower lobe.
Fig 3. Enhanced chest CT scan shows persistent irregular shape consolidation in left lower lobe with suspicious feeding vessel from the descending thoracic aorta.
Brief Review
The patient, with no notable medical history, was admitted after an incidental finding of consolidation on a low-dose chest CT during a screening. The patient had no presenting symptoms, and blood tests showed no abnormalities. Her chest radiography appeared normal, and the consolidation seen on the CT was not definitely observed on the chest radiography. A follow-up with low-dose chest CT was conducted to rule out malignancy. Over approximately three years of follow-up, the extent of the consolidation gradually increased. In two transbronchial lung biopsy (TBLB) instances, findings indicated chronic nonspecific inflammation, and the PET-CT showed equivocal FDG uptake, leading the medical team to plan surgery to exclude malignancy definitively. On the Enhanced CT taken a day before the surgery, the extent of the consolidation in the left lower lobe slightly increased. A systemic artery branching from the descending thoracic aorta and supplying the affected lung parenchyma was also identified. The surgical pathology results showed chronic inflammation associated with pulmonary sequestration, which had a feeding vessel.
Pulmonary sequestration (PS) is a malformation of the lower respiratory tract, consisting of a nonfunctioning mass of the lung tissue that lacks normal communication with the tracheobronchial tree and receives its blood supply from one or more aberrant systemic arteries. Despite being a relatively rare condition (accounting for 0.15% to 6.4% of all congenital pulmonary malformations), it is the second most common congenital lung malformation. Based upon the pleural investment of the sequestered lung parenchyma, PS can be classified as either intralobar or extralobar. Intralobar sequestration is characterized by sharing the same visceral pleura lining of the native lung and has a venous drainage into the pulmonary veins. Conversely, extralobar sequestration has its own viscerl pleural investment outside the normal lung and drains into a systemic vein, forming an accessory lobe.
In 1.5% of intralobar sequestration may also be seen as an irregular lesion mimicking a malignant tumor. Pleural effusion may rarely occur, and other findings such as focal bronchiectasis, subsegmental atelectasis, decreased lung volume have also been described. CT and MRI play a pivotal role in the diagnosis of PS, owing to their ability to accurately depict its anatomical location and structure and to identify its arterial supply and venous drainage.
Surgical resection with isolation and division of anomalous systemic feeding arteries is the treatment of choice for PS, and is recommended because of the likelihood of recurrent infection, the need for larger resection if the sequestration becomes chronically infected, the risk of hemorrhage and the reported development of malignancy, but also in asymptomatic patients to avoid infection.
Low-dose, non-contrast scans are widely used for screening and follow-up purposes. However, if there is suspicion of malignancy or surgery is being planned, an enhanced CT scan is necessary. Additionally, if persistent consolidation is observed in the left lower lobe, it is essential to consider the possibility of pulmonary sequestration and carefully check for the presence of a feeding vessel.
References
1. Frazier, Aletta Ann, M. L. Rosado de Christenson, J. Thomas Stocker, and Philip A. Templeton. "Intralobar sequestration: radiologic-pathologic correlation." Radiographics 17, no. 3 (1997): 725-745.
2. Gabelloni, Michela, Lorenzo Faggioni, Sandra Accogli, Giacomo Aringhieri, and Emanuele Neri. "Pulmonary sequestration: what the radiologist should know." Clinical imaging 73 (2021): 61-72.
Keywords

No. of Applicants : 61

▶ Correct Answer : 43/61,  70.5%
  • - Ishikawa Matto Central Hospital , Japan MANABU AKIMOTO
  • - medical scanning , Japan HIROAKI ARAKAWA
  • - The University of Tokyo Hospital , Japan JUN KANZAWA
  • - ZIGONG TCM HOSPITAL OF CHINA , China CAO CUN YOU
  • - Shiga University of Medical Science , Japan AKITOSHI INOUE
  • - Kyoto University , Japan AKIHIKO SAKATA
  • - McGill University Health Center , Canada ALEXANDRE SEMIONOV
  • - Oita university , Japan AYUMI KAMEI
  • - , Korea (South) DONG-HO BANG
  • - Healthy Longevity Medical Center , Japan SHIN-ICHI CHO
  • - Other , Korea (South) SEONGSU KANG
  • - , Korea (South) JIN YOUNG LEE
  • - Other , Korea (South) DOWOO KIM
  • - Secomedic Hospital , Japan FUMINORI MIYOSHI
  • - Seoul Medical Center , Korea (South) HYUK GI HONG
  • - university of montreal , Canada Andrei Bogdan Gorgos I
  • - University of Yamanashi , Japan TAKAAKI HASHIMOTO
  • - Osaka University , Japan AKINORI HATA
  • - Other , Korea (South) HYEJOO PARK
  • - The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
  • - University of Yamanashi , Japan HIROAKI WATANABE
  • - Nankai medical center , Japan NORITAKA KAMEI
  • - Dong-A University, College of Medicine , Korea (South) KI-NAM LEE
  • - Other , Korea (South) CHAEHUN LIM
  • - Osaka Metropolitan University Hospital , Japan SHU MATSUSHITA
  • - , Japan SHUNJIRO NOGUCHI
  • - Jichi Medical University, School of Medicine , Japan MITSURU MATSUKI
  • - University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
  • - Shiga General Hospital , Japan YUSAKU MORIBATA
  • - Avrasya Hospital/ISTANBUL , Turkey MURAT ULUSOY
  • - Osaka metropolitan university Hospital , Japan TATSUSHI OURA
  • - GHICL , France MANUEL TOLEDANO
  • - Dokkyo Medical University , Japan HIROAKI ARAKAWA
  • - , China MING LU
  • - Paras hospital, Panchkula , India SHALEEN RANA
  • - Yonsei University,Severance Hospital , Korea (South) SEO BUM CHO
  • - Fukuoka university , Japan KEISUKE SATO
  • - Kantou Rousai Hospital , Japan KAORU SUMIDA
  • - , Sweden MOHAMAD TLASS
  • - The Catholic University of Korea Yoeuido St. Mary , Korea (South) CHAWOONG JEON
  • - the first affiliatited hospital of nanjing medical univercity , China HAI XU
  • - Juntendo University , Japan YUTAKA IKENOUCHI
  • - Jiangsu province hospital , China WANGJIAN ZHA
▶ Correct Answer as Differential Diagnosis : 11/61,  18.0%
  • - , Japan SUZUNE TSUKAMOTO
  • - Kyoto City Hospital , Japan YUSUKE UTSUNOMIYA
  • - NIMS, HYDERABAD , India BHASKAR K
  • - Vita Hospital , Brazil DIOGO LAGO PINHEIRO
  • - Oita University, Faculty of Medicine , Japan FUMITO OKADA
  • - University of Yamanashi , Japan HIROYUKI MORISAKA
  • - , Japan YOSHIKI ISHII
  • - Mie university , Japan SHIKO OKABE
  • - Kyoto University , Japan SHO KOYASU
  • - Hyogo Prefectural Kobe Children , Japan SHUHEI NORIMOTO
  • - University of Yamanashi , Japan KOJIRO ONOHARA
▶ Semi-Correct Answer : 2/61,  3.3%
  • - Saitama-Sekishinkai Hosptal , Japan MIHOKO YAMAZAKI
  • - Toyota Kosei Hospital , Japan YUKI HAYASHI
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