대한흉부영상의학회 Weekly Chest Cases

Case No : 1419 Date 2024-12-30

Courtesy of Byunggeon Park, Kyung Min Shin / Kyungpook National University Chilgok Hospital
Age/Sex 63 / F
Chief ComplaintIncidentally found lung nodule

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Figure 2
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Figure 4

Diagnosis With Brief Discussion

Diagnosis: Bronchiolar Adenoma/Pulmonary Ciliated Muconodular Papillary Tumor
Radiologic Findings: Figures 1 and 2. Axial and coronal chest CT show a 1.2cm subsolid nodule in the right lower lobe.
Figure 3. FDG PET-CT scan shows no FDG uptake in the nodule.
Figure 4. Chest CT obtained 10 years ago shows a 0.5cm nodule in the right lower lobe
Brief Review: The ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor first reported and named by Ishikawa in 2002. In 2018, Chang et al. expanded its description and proposed diagnostic terminology for bronchial adenoma (BA). This tumor has now been added to the latest WHO classification of thoracic tumors (5th edition). Its histological characteristic is bilayer bronchiolar-type proliferation with a continuous layer of basal cells. With the continuous supplementation of case reports, the biological characteristics of this tumor are gradually being recognized. In the published literature, BA/CMPT mostly grows in isolation. In addition, the potential of BA/CMPT for malignant transformation has been controversial. On computed tomography (CT) images, BA often presents as a peripheral irregular-shaped small solid nodule, ground-glass nodule (GGN), or subsolid GGN with a central cavity, which could be easily misdiagnosed as adenocarcinoma in situ (AIS) or minimally invasive adenocarcinoma (MIA).
References: 1. SUN, Jinju, et al. CT texture analysis for differentiating bronchiolar adenoma, adenocarcinoma in situ, and minimally invasive adenocarcinoma of the lung. Frontiers in Oncology, 2021, 11: 634564.
2. SUN, Jiaen, et al. Multiple bronchiolar adenomas/ciliated muconodular papillary tumors of the bilateral lung with tumor budding and potential malignant transformation into squamous cell carcinoma: a case report and literature review. Translational Lung Cancer Research, 2023, 12.7: 1611.
Keywords

No. of Applicants : 69

▶ Correct Answer : 26/69, 37.7%

- , Japan SUZUNE TSUKAMOTO
- medical scanning , Japan HIROAKI ARAKAWA
- Shiga University of Medical Science , Japan AKITOSHI INOUE
- Kyoto University , Japan AKIHIKO SAKATA
- Kyoto City Hospital , Japan YUSUKE UTSUNOMIYA
- Healthy Longevity Medical Center , Japan SHIN-ICHI CHO
- Secomedic Hospital , Japan FUMINORI MIYOSHI
- Osaka University , Japan AKINORI HATA
- The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
- , Japan YOSHIKI ISHII
- Other , Korea (South) MARI A
- Osaka Metropolitan University Hospital , Japan SHU MATSUSHITA
- , Japan SHUNJIRO NOGUCHI
- University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
- Osaka metropolitan university Hospital , Japan TATSUSHI OURA
- Mie university , Japan SHIKO OKABE
- Dokkyo Medical University , Japan HIROAKI ARAKAWA
- Kyoto University , Japan SHO KOYASU
- , Japan SHUHEI NORIMOTO
- Yonsei University,Severance Hospital , Korea (South) SEO BUM CHO
- Kantou Rousai Hospital , Japan KAORU SUMIDA
- Matsunami General Hospital , Japan TARO TAKEDA
- Shiga University of Medical Science , Japan RYO UEMURA
- Toyota Kosei Hospital , Japan YUKI HAYASHI
- the first affiliatited hospital of nanjing medical univercity , China HAI XU
- University of Yamanashi , Japan KOJIRO ONOHARA

▶ Correct Answer as Differential Diagnosis : 1/69, 1.4%

- Fukuoka university , Japan KEISUKE SATO

대한흉부영상의학회 Korean Society of Thoracic Radiology

Archive of Old Cases

Case No : 1419 Date 2024-12-30

Discussion

No. of Applicants : 69