Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Lemierre syndrome
- Radiologic Findings
- Figure 1. Chest posteroanterior (PA) radiograph demonstrates multifocal, peripheral, ill-defined, and nodular opacities in both lungs.
Figure 2. Axial chest computed tomography (CT) images reveal multiple subpleural ground-glass opacities (GGOs) and peripheral consolidations in both lungs. Some lesions exhibit the reverse halo sign and the feeding vessel sign.
Figure 3. Contrast-enhanced neck CT demonstrates right internal jugular vein thrombophlebitis, characterized by a non-opacified thrombus within the vein and surrounding soft tissue inflammation.
- Brief Review
- Lemierre syndrome is a rare but serious condition characterized by septic thrombophlebitis of the internal jugular vein (IJV), typically following an oropharyngeal infection such as tonsillopharyngitis or a peritonsillar abscess. It primarily affects young, healthy individuals in their 20s to 30s, with Fusobacterium necrophorum being the most common causative organism. The infection spreads to the IJV, forming a thrombus, and septic emboli disseminate through the bloodstream, most commonly affecting the lungs.
Neck CT with contrast often shows a non-opacified thrombus in the IJV with surrounding soft tissue inflammation. Chest X-rays may demonstrate rounded opacities, complementing the findings on CT. However, chest x-ray appears normal in 10% of patients. Chest CT typically reveals multiple subpleural nodules or wedge-shaped consolidations with GGOs, some displaying the reverse halo sign and feeding vessel sign, indicative of septic emboli and infarction.
- References
- 1. Harper LK, Pflug K, Raggio B, April D, Milburn JM. Clinical Images: Lemierre Syndrome: The Forgotten Disease? Ochsner J. 2016 Spring;16(1):7-9.
2. Byrne, S.C., Hammer, M.M., Thomas, R. (2022). Imaging of Pulmonary Infections. In: Patlas, M.N., Katz, D.S., Scaglione, M. (eds) Atlas of Emergency Imaging from Head-to-Toe. Springer, Cham.
- Keywords