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Weekly Chest CasesArchive of Old Cases

Case No : 1439 Date 2025-05-19

  • Courtesy of Jiyoung Song, Eui Jin Hwang / Seoul National University Hospital
  • Age/Sex 18 / F
  • Chief ComplaintChest X-ray abnormality
  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4

Diagnosis With Brief Discussion

Diagnosis
Castleman disease, Hyaline vascular type
Radiologic Findings
Fig 1. Chest radiography shows bulging mass opacity at right hilar area.
Fig 2-3. Chest CT images show large mass at right paravertebral area, with internal calcification. Homogenous enhancement is seen after the administration of intravenous contrast media.
Brief Review
Castleman disease is an uncommon polyclonal lymphoproliferative disease. Pathologically, there are two types: Hyaline vascular type, plasma cell type, and human herpesvirus 8 (HHV-8)-associated Castleman disease. Hyalin vascular type comprised 90% of Castleman disease. Based on biological behavior, Castleman disease can also be classified into unicentric form and multicentric form, based on the extent of local lymph node involvement.
Most of hyaline vascular type Castleman disease may manifest as unicentric form. CT image may show asolytary enlarged lymph node or localized mass the demonstrates homogenous intense enhancement after contrast material administration.
References
1. Bonekamp D, Horton KM, Hruban RH et al. Castleman disease: the great mimic. Radiographcs 2011;31:1793-1807.
2. Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control 2014;21:266-278.
Keywords

No. of Applicants : 67

▶ Correct Answer : 19/67,  28.4%
  • - , Japan SUZUNE TSUKAMOTO
  • - Huanggang Central Hospital , China ZHOU GANG
  • - Fukuoka university , Japan KEISUKE SATO
  • - Shiga University of Medical Science , Japan AKITOSHI INOUE
  • - Shiga General Hospital , Japan YUSAKU MORIBATA
  • - , Japan SHUNJIRO NOGUCHI
  • - The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
  • - Kyoto University , Japan AKIHIKO SAKATA
  • - University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
  • - Healthy Longevity Medical Center , Japan SHIN-ICHI CHO
  • - University of Yamanashi , Japan KOJIRO ONOHARA
  • - the first affiliatited hospital of nanjing medical univercity , China HAI XU
  • - Jichi Medical University, School of Medicine , Japan MITSURU MATSUKI
  • - Toyota Kosei Hospital , Japan YUKI HAYASHI
  • - IUHW Narita Hospital , Japan ISSEI FUKUDA
  • - Kantou Rousai Hospital , Japan KAORU SUMIDA
  • - Secomedic Hospital , Japan FUMINORI MIYOSHI
  • - , Japan YOSHIKI ISHII
  • - Kyoto University , Japan SHO KOYASU
▶ Correct Answer as Differential Diagnosis : 7/67,  10.4%
  • - , Korea (South) DONG-HO BANG
  • - University of Yamanashi , Japan TAKAAKI HASHIMOTO
  • - Osaka metropolitan university Hospital , Japan TATSUSHI OURA
  • - Oita university , Japan AYUMI KAMEI
  • - , Italy PAOLO BALDASSARI
  • - University of Yamanashi , Japan HIROYUKI MORISAKA
  • - , Japan YUMI MAEHARA
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Each Case of This Site Supplied by the Members of KSTR.
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Current Editor : Eui Jin Hwang, M.D., Ph.D Email : weeklychestcases@gmail.com

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