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Weekly Chest CasesArchive of Old Cases

Case No : 1439 Date 2025-05-19

  • Courtesy of Jiyoung Song, Eui Jin Hwang / Seoul National University Hospital
  • Age/Sex 18 / F
  • Chief ComplaintChest X-ray abnormality
  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4

Diagnosis With Brief Discussion

Diagnosis
Castleman disease, Hyaline vascular type
Radiologic Findings
Fig 1. Chest radiography shows bulging mass opacity at right hilar area.
Fig 2-3. Chest CT images show large mass at right paravertebral area, with internal calcification. Homogenous enhancement is seen after the administration of intravenous contrast media.
Brief Review
Castleman disease is an uncommon polyclonal lymphoproliferative disease. Pathologically, there are two types: Hyaline vascular type, plasma cell type, and human herpesvirus 8 (HHV-8)-associated Castleman disease. Hyalin vascular type comprised 90% of Castleman disease. Based on biological behavior, Castleman disease can also be classified into unicentric form and multicentric form, based on the extent of local lymph node involvement.
Most of hyaline vascular type Castleman disease may manifest as unicentric form. CT image may show asolytary enlarged lymph node or localized mass the demonstrates homogenous intense enhancement after contrast material administration.
References
1. Bonekamp D, Horton KM, Hruban RH et al. Castleman disease: the great mimic. Radiographcs 2011;31:1793-1807.
2. Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control 2014;21:266-278.
Keywords

No. of Applicants : 67

▶ Correct Answer : 19/67,  28.4%
  • - , Japan SUZUNE TSUKAMOTO
  • - IUHW Narita Hospital , Japan ISSEI FUKUDA
  • - Shiga University of Medical Science , Japan AKITOSHI INOUE
  • - Kyoto University , Japan AKIHIKO SAKATA
  • - Healthy Longevity Medical Center , Japan SHIN-ICHI CHO
  • - Secomedic Hospital , Japan FUMINORI MIYOSHI
  • - The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
  • - , Japan YOSHIKI ISHII
  • - , Japan SHUNJIRO NOGUCHI
  • - Jichi Medical University, School of Medicine , Japan MITSURU MATSUKI
  • - University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
  • - Shiga General Hospital , Japan YUSAKU MORIBATA
  • - Kyoto University , Japan SHO KOYASU
  • - Fukuoka university , Japan KEISUKE SATO
  • - Kantou Rousai Hospital , Japan KAORU SUMIDA
  • - Toyota Kosei Hospital , Japan YUKI HAYASHI
  • - the first affiliatited hospital of nanjing medical univercity , China HAI XU
  • - University of Yamanashi , Japan KOJIRO ONOHARA
  • - Huanggang Central Hospital , China ZHOU GANG
▶ Correct Answer as Differential Diagnosis : 7/67,  10.4%
  • - Oita university , Japan AYUMI KAMEI
  • - , Korea (South) DONG-HO BANG
  • - , Italy PAOLO BALDASSARI
  • - University of Yamanashi , Japan TAKAAKI HASHIMOTO
  • - University of Yamanashi , Japan HIROYUKI MORISAKA
  • - Osaka metropolitan university Hospital , Japan TATSUSHI OURA
  • - , Japan YUMI MAEHARA
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Each Case of This Site Supplied by the Members of KSTR.
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Current Editor : Eui Jin Hwang, M.D., Ph.D Email : weeklychestcases@gmail.com

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