Weekly Chest CasesArchive of Old Cases

Case No : 1471 Date 2025-12-29

  • Courtesy of Ji Young Lee / Seoul National University Hospital
  • Age/Sex 32 / F
  • Chief ComplaintIncidentally found mediastinal mass
  • Figure 1
  • Figure 2
  • Figure 3

Diagnosis With Brief Discussion

Diagnosis
Castleman disease, Hyaline vascular type
Radiologic Findings
Fig 1. Chest radiography shows bulging mass opacity at right paratracheal area.
Fig 2-3. Chest CT images show 5.3cm mass at right paratracheal area, with homogenous enhancement.
Brief Review
Castleman disease is an uncommon polyclonal lymphoproliferative disease. Pathologically, there are two types: Hyaline vascular type, plasma cell type, and human herpesvirus 8 (HHV-8)-associated Castleman disease. Hyalin vascular type comprised 90% of Castleman disease. Based on biological behavior, Castleman disease can also be classified into unicentric form and multicentric form, based on the extent of local lymph node involvement.
Most of hyaline vascular type Castleman disease may manifest as unicentric form. CT image may show asolytary enlarged lymph node or localized mass the demonstrates homogenous intense enhancement after contrast material administration.
References
1. Bonekamp D, Horton KM, Hruban RH et al. Castleman disease: the great mimic. Radiographcs 2011;31:1793-1807.
2. Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control 2014;21:266-278.
Keywords

No. of Applicants : 83

▶ Correct Answer : 52/83,  62.7%
  • - Kyeongpook National University Hospital , Korea (South) JOHN BAEK
  • - Saitama-Sekishinkai Hosptal , Japan MIHOKO YAMAZAKI
  • - , Japan SUZUNE TSUKAMOTO
  • - The University of Tokyo Hospital , Japan ISSEI FUKUDA
  • - ZIGONG TCM HOSPITAL OF CHINA , China CAO CUN YOU
  • - Kyoto University , Japan AKIHIKO SAKATA
  • - Affilitated Hospital of Jining Medical college , China JIANG SHENG HUA
  • - , Turkey ARMAGAN SARAC
  • - Chonnam National University Hospital , Korea (South) CHAEWON SONG
  • - , Korea (South) KYUNG HYUN WOO
  • - Samsung Medical Center , Korea (South) HYUNGIN PARK
  • - , Korea (South) DONG-HO BANG
  • - the First Affiliated Hospital of NanJing Medical University , China AIPING CHEN
  • - Chonnam National University Hospital , Korea (South) JUNYEOL YANG
  • - Vita Hospital , Brazil DIOGO LAGO PINHEIRO
  • - Kyeongpook National University Hospital , Korea (South) JUNGMIN LEE
  • - Other , Korea (South) SEONGSU KANG
  • - , Korea (South) JIN YOUNG LEE
  • - Kyung Hee University Medical Hospital , Korea (South) INKEON YEO
  • - Chonbuk National University Hospital , Korea (South) YONG HWAN JO
  • - Oita University, Faculty of Medicine , Japan FUMITO OKADA
  • - university of montreal , Canada Andrei Bogdan Gorgos I
  • - University of Yamanashi , Japan TAKAAKI HASHIMOTO
  • - Osaka University , Japan AKINORI HATA
  • - University of Yamanashi , Japan HIROYUKI MORISAKA
  • - The University of Tokyo Hospital , Japan TOSHIHIRO FURUTA
  • - Nara Medical University , Japan AYA YAMADA
  • - , Japan YOSHIKI ISHII
  • - Narayana Multispeciality Hospital Jaipur Rajasthan , India JAINENDRA JAIN
  • - Other , Korea (South) CHAEHUN LIM
  • - , Japan SHUNJIRO NOGUCHI
  • - University of Tsukuba, Dept of Radiology , Japan MANABU MINAMI
  • - Shiga General Hospital , Japan YUSAKU MORIBATA
  • - Aichi Medical University , Japan HIROAKI OKADA
  • - Seoul Medical Center , Korea (South) YONGJOO LEE
  • - Seoul Medical Center , Korea (South) HANSEUL CHO
  • - Korea University Anam Hospital , Korea (South) KYU-CHONG LEE
  • - , Japan MATSUNO MAI
  • - University of Tsukuba Hospital , Japan SODAI HOSHIAI
  • - Kyung Hee University Medical Hospital , Korea (South) JEONG TAEK YOON
  • - Yonsei University,Severance Hospital , Korea (South) SEO BUM CHO
  • - Fukuoka university , Japan KEISUKE SATO
  • - Kantou Rousai Hospital , Japan KAORU SUMIDA
  • - Matsunami General Hospital , Japan TARO TAKEDA
  • - Ehime University , Japan KOTARO MATSUMOTO
  • - Sotiria Hospital, Athens , Greece VASILIOS TZILAS
  • - , Japan YUMI MAEHARA
  • - Toyota Kosei Hospital , Japan YUKI HAYASHI
  • - the first affiliatited hospital of nanjing medical univercity , China HAI XU
  • - University of Yamanashi , Japan KOJIRO ONOHARA
  • - Chonnam National University Hospital , Korea (South) JAEBONG YANG
  • - Jiangsu province hospital , China WANGJIAN ZHA
▶ Correct Answer as Differential Diagnosis : 21/83,  25.3%
  • - Shiga University of Medical Science , Japan AKITOSHI INOUE
  • - McGill University Health Center , Canada ALEXANDRE SEMIONOV
  • - Kyoto University Hospital , Japan YUSUKE UTSUNOMIYA
  • - , Italy PAOLO BALDASSARI
  • - , China FANG YING GEN
  • - Secomedic Hospital , Japan FUMINORI MIYOSHI
  • - Seoul Medical Center , Korea (South) HYUK GI HONG
  • - Seoul Medical Center , Korea (South) HATAEK JEONG
  • - University of Yamanashi , Japan HIROAKI WATANABE
  • - University Clinical Centre in Gdansk , Poland LUKASZ BUDYNKO
  • - Osaka Metropolitan University Hospital , Japan SHU MATSUSHITA
  • - Etlik City Hospital, Ankara , Turkey MERIC TUZUN
  • - Jichi Medical University, School of Medicine , Japan MITSURU MATSUKI
  • - GOP Avrasya Hospital/ISTANBUL , Turkey MURAT ULUSOY
  • - , Japan TOMOHIRO KAWAJI
  • - Kyoto University , Japan SHO KOYASU
  • - Kobe Children , Japan SHUHEI NORIMOTO
  • - , Sweden MOHAMAD TLASS
  • - Ehime University , Japan TOMOHISA OKADA
  • - Nara medical university , Japan HIROHIDE WATANABE
  • - The Catholic University of Korea Yoeuido St. Mary , Korea (South) CHAWOONG JEON
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