Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Sarcoidosis
- Radiologic Findings
- Fig 1. Chest PA shows bilateral hilar bulding opacity
Fig 2. Axial CT images with mediastinal setting show bilateral multiple conclomerated mediastinal lymphadenopathy
Fig 3. Axial CT images with lung setting show multifocal patchy GGO in both lung
- Brief Review
- For diagnostic evaluation, the patient underwent EBUS biopsy of the mediastinal lymph nodes, which revealed non-caseating granulomas, suspicious for sarcoidosis. Based on these findings, a final diagnosis of sarcoidosis was made
Sarcoidosis is a multisystem granulomatous disorder characterized by the development of noncaseating granulomas in various organs. The clinical features are often nonspecific (e.g., cough, dyspnea, and chest pain) and can be seen in 9%–19% of cases.
Sarcoidosis usually presents with asymptomatic lymphadenopathy with or without pulmonary infiltrations. Bilateral hilar lymphadenopathy is the most common radiological finding. Mediastinal lymphadenopathy can also be seen and is often associated with the presence of pulmonary infiltrates. The presence of pulmonary infiltrations have been reported in approximately 60% of patients.
Additionally, it can present with small nodules that mostly measure less than 3 mm in diameter and nodular thickening along the lymphatics in the bronchovascular sheath and, to a lesser extent, in the interlobular septa and subpleural lung regions. This distribution is referred to as perilymphatic. In addition, upper lobe predominance is common, but this finding can vary. Most sarcoid granulomas can resolve spontaneously; however, sarcoid granulomas can also progress to fibrosis
Given the high probability of spontaneous resolution in patients with newly diagnosed early-stage pulmonary sarcoidosis, it may be preferable to monitor the condition without applying any specific treatment in the early stages. Patients showing progression of symptoms, worsening radiographic appearance, or decreasing pulmonary function should be considered for treatment. Systemic corticosteroids are the mainstay of treatment for sarcoidosis.
- References
- 1. Ganeshan D, Menias CO, Lubner MG, et al. Sarcoidosis from head to toe: what the radiologist needs to know. Radiographics 2018; 38:1180–1200.
2. Park HJ, Jung JI, Chung MH et al. Typical and Atypical Manifestations of Intrathoracic Sarcoidosis. Korean J Radiol. 2009 Nov-Dec;10(6):623-631.
3. Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S. Radiologic manifestations of sarcoidosis in various organs. Radiographics 2004;24:87–104.
- Keywords