Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Subacute invasive pulmonary aspergillosis
- Radiologic Findings
- Figure 1. Multiple small nodules are noted in both lungs with cavitary consolidation in right apex.
Figure 2-3. An approximately 4.5cm-sized thick walled cavity with adjacent fibrotic bands is seen in right upper lobe with randomly distributed multiple small nodules in both upper lobes.
Figure 4. On chest X-ray after 1 year, there is increasing cavitary consolidation in RULZ while other findings remain constant.
Figure 5-8. Chest CT scans after 1 year show substantially thickened wall of the cavity with unchanged multiple nodules in both upper lobes.
The patient had a history of tuberculosis and pneumoconiosis. Aspergillus fumigatus was detected in culture by PCNA, and a definitive diagnosis of subacute invasive pulmonary aspergillosis was made.

Figure 9. Increasing wall thickness of cavity is noted on serial CT images: overall size and wall thickness continues to increase until the final month.
- Brief Review
- Subacute invasive pulmonary aspergillosis (SIPA) is a rapidly progressive fungal infection lasting fewer than three months and arising from pre
- Please refer to
Case 103, Case 508, Case 578, Case 1159, -
- References
- 1. Barac A, Kosmidis C, Alastruey-Izquierdo A, et al. Chronic pulmonary aspergillosis update: A year in review. Med Mycol. 2019 Apr 1;57(Supplement_2):S104-S109
2. Kanj A, Abdallah N, Soubani AO. The spectrum of pulmonary aspergillosis. Respir Med. 2018 Aug;141:121-131
3. Denning DW, Cadranel J, Beigelman-Aubry C, et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016 Jan;47(1):45-68.
- Keywords
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lung, chronic pulmonary aspergillosis, subacute invasive pulmonary aspergillosis,