대한흉부영상의학회 Korean Society of Thoracic Radiology

Discussion

Diagnosis With Brief Discussion

Diagnosis

Cystic lung disease in Down syndrome (trisomy 21)

Radiologic Findings

Fig 1. Chest PA shows diffuse subpleural cysts in both lung field, especially left lung field.
Fig 2-4. CT scans reveal multiple small subpleural cysts in bilateral lungs with greater involvement of both upper lung zone.

Brief Review

Down syndrome (trisomy 21) is a common chromosomal disorder occurring in approximately 1 out of 750 liver births. Many factors contribute to the manifestation of respiratory system disorders among children with trisomy 21, encompassing structural abnormalities of the airways and lungs, recurrent lower respiratory tract infections and obstructive sleep apnoea.
Cystic lung disease in children with trisomy 21 was first described in 1986 by Joshi et al from the autopsy findings of two infants exhibiting lung cysts and congenital heart disease. On chest computed tomography (CT), it is characterized by a rim of small 1

References

1. Singh, A., Coblentz, A., Hadian, F., Chami, R., Traubici, B., & Manson, D. E. (2023). Subpleural pulmonary cysts in children: Associations beyond Trisomy 21. Pediatric pulmonology, 58(12), 3498

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